Blaque Sigma Product Guides
Select your product below for step-by-step setup instructions and clinical protocols. Everything you need — clearly laid out, always accessible.
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Select Your Product Guide
Choose from the available product guides below. Each guide includes a full product overview, what's in the box, preparation steps, and detailed clinical administration protocols — designed for both practitioners and patients.
Glutathione (IM & IV)
Full preparation and clinical administration guide for intramuscular and intravenous glutathione protocols.
Vitamin Drip Protocol
Step-by-step IV drip setup guide including dosage, dilution ratios, and administration best practices.
Peptide Booster Series
Reconstitution and injection protocols for the complete Blaque Sigma peptide booster product range.
More product guides are added regularly. Check back often or contact support to request a specific protocol guide.
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The Blaque Sigma support team is available to assist with product questions, order enquiries, clinical guidance, and technical support. Reach us through any of the channels below — we typically respond within one business day.
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For detailed enquiries, order issues, or clinical questions, email our team at:
support@blaquesigma.com
Response time: within 24 business hours.
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For quick questions and real-time protocol guidance, message us directly on WhatsApp. Our clinical team is available Monday–Friday, 9am–6pm.
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Glutathione (IM & IV)
The ultimate systemic antioxidant for profound cellular detoxification and radiant skin luminosity.
Professional Clinical Guide
BlaqueSigma
Product Overview & Clinical Mechanism
Classification
Systemic Antioxidant & Advanced Melanin Inhibitor
Core Function
A potent tripeptide acting as the body's master antioxidant — neutralising free radicals, detoxifying the liver, and inhibiting tyrosinase to shift melanogenesis from dark eumelanin to lighter pheomelanin, resulting in systemic skin brightening.
Key Active Ingredients
L-Glutathione (Reduced)
The biologically active form. Scavenges reactive oxygen species (ROS), promotes cellular repair, and reduces hyperpigmentation.
Ascorbic Acid (Vitamin C)
Synergistic co-ingredient that stabilises Glutathione, prevents oxidisation, and boosts native collagen synthesis.
Treatment Indications & What's in the Box
Primary Indications
- Generalised skin brightening
- Severe hyperpigmentation & melasma
- Cellular oxidative stress
- Chronic fatigue
- Liver detoxification
What's in the Box
- L-Glutathione (Reduced) Lyophilised Powder Vials (600mg or 1200mg)
- Vitamin C (Ascorbic Acid) Liquid Ampoules (500mg/5ml)
- Sterile Water for Injection (Bacteriostatic Water) Ampoules
Systemic treatment affects the entire cutaneous organ and internal cellular environment via IV or IM routes.
Step 1
Preparation & Setup
Assessment
Evaluate patient vital signs, confirm hydration status, and rule out contraindications such as severe asthma or sulfa allergies.
Reconstitution
Draw up Sterile Water or Vitamin C solution and inject into the Glutathione powder vial. Gently swirl — do not shake — until fully dissolved.
IV Drip Prep
Inject reconstituted mixture into a 50–250ml bag of 0.9% Normal Saline. Prime the IV line to ensure no air bubbles are present.
IM Preparation
Draw reconstituted mixture (typically 600mg Glutathione with 4ml sterile water) into a syringe fitted with a 21G or 23G needle for deep intramuscular injection.
Step 2
Clinical Administration
Intravenous (IV) Drip Protocol
Locate a viable vein (typically the median cubital vein) and insert a 22G or 24G IV cannula. Connect the primed IV line and set the drip rate for a slow, controlled infusion over 15 to 30 minutes.
Intramuscular (IM) Protocol
Utilise the Z-track method for deep gluteal injection (upper outer quadrant) to minimise subcutaneous irritation and product leakage.
Session Frequency
Administer 1 to 2 times per week for an initial cycle of 10 to 12 sessions. Maintenance: 1 to 2 sessions per month.
Step 3
Immediate Post-Care
Extraction
Carefully remove the IV cannula or IM needle. Apply firm pressure with sterile gauze for 2–3 minutes to prevent haematoma formation.
Observation
Keep the patient under observation for 10–15 minutes post-infusion to monitor for adverse reactions such as dizziness or mild hypotension.
Hydration Advice
Instruct the patient to drink at least 500ml of water immediately following the session to aid systemic circulation and cellular uptake.
Standard Clinical Protocol & Dosage
1200mg
Max Per Session
600–1200mg Glutathione, combined with 500–1000mg Vitamin C
2400mg
Weekly Maximum
Do not exceed without comprehensive physician oversight and renal monitoring
12
Initial Sessions
10–12 sessions at 1–2 per week for a full brightening cycle
Practitioner Guidelines
- Aseptic Protocol: Strict sterile technique is mandatory for reconstitution and venous access
- Hydration Verification: Confirm adequate hydration prior to cannula insertion
- Speed of Administration: Slow drip (15–30 min) is imperative — rapid infusion risks adverse reactions and rapid renal excretion before cellular absorption
Comprehensive Aftercare
1
0–24 Hours
Keep the IV/IM site clean and dry. Apply a cold compress for minor bruising. Avoid heavy alcohol consumption to allow the liver to process the antioxidant payload.
2
24 hrs – 2 Weeks
Maintain high water intake (2–3 litres daily) to flush released toxins. Strict adherence to broad-spectrum SPF 50+ is required as skin may become more photosensitive while melanin production is suppressed.
3
Expected Sensations
Mild tenderness or a small bruise at the IV/IM site is normal. Some patients report a mild, temporary metallic taste during infusion or a feeling of deep relaxation post-treatment.
Contraindications, Safety & Pro Tips
Contraindications
Asthma
May trigger bronchospasms; avoid in severe or uncontrolled asthma.
Allergies
Contraindicated with known Glutathione or severe sulfa allergies (cross-reactivity risk).
Organ Dysfunction
Contraindicated in severe renal failure or advanced hepatic disease unless cleared by a specialist.
Pregnancy & Lactation
Safety not established; strictly contraindicated.
Pro Tips & Best Practices
Clinical Pearl: Always pair Glutathione with high-dose Vitamin C. It acts as a catalyst, keeping Glutathione in its active (reduced) state and maximising tyrosinase-inhibiting efficacy.
Safety Warning: Avoid rapid IV pushes. Administering too quickly can cause sudden hypotension, dizziness, or stomach cramping. Always use a controlled drip over 15–30 minutes.
Retention Strategy: Sell treatments in "Cellular Detox & Brightening Cycles" of 10 sessions. Patients rarely see profound results until session 5 or 6 — a package ensures commitment to the full clinical timeline.
BlaqueSigma Professional Disclaimer
For Professional Use Only. This guide is intended for educational and reference purposes for certified aesthetic practitioners. It does not replace formal medical training. Practitioners are solely responsible for patient assessment, sterile application, and adhering to local regulatory guidelines. No refunds are provided on professional consumables.
Certified Practitioners Only
Ensure all treatments are performed by qualified, licensed professionals.
Regulatory Compliance
Adhere strictly to your local regulatory and clinical governance guidelines.
Patient Safety First
Thorough patient assessment and informed consent are mandatory before every session.
Glutathione (IM & IV)
The ultimate systemic antioxidant for profound cellular detoxification and radiant skin luminosity.
Professional Clinical Guide
BlaqueSigma
Product Overview & Clinical Mechanism
Classification
Systemic Antioxidant & Advanced Melanin Inhibitor
Core Function
A potent tripeptide acting as the body's master antioxidant — neutralising free radicals, detoxifying the liver, and inhibiting tyrosinase to shift melanogenesis from dark eumelanin to lighter pheomelanin, resulting in systemic skin brightening.
Key Active Ingredients
L-Glutathione (Reduced)
The biologically active form. Scavenges reactive oxygen species (ROS), promotes cellular repair, and reduces hyperpigmentation.
Ascorbic Acid (Vitamin C)
Synergistic co-ingredient that stabilises Glutathione, prevents oxidisation, and boosts native collagen synthesis.
Treatment Indications & What's in the Box
Primary Indications
- Generalised skin brightening
- Severe hyperpigmentation & melasma
- Cellular oxidative stress
- Chronic fatigue
- Liver detoxification
What's in the Box
- L-Glutathione (Reduced) Lyophilised Powder Vials (600mg or 1200mg)
- Vitamin C (Ascorbic Acid) Liquid Ampoules (500mg/5ml)
- Sterile Water for Injection (Bacteriostatic Water) Ampoules
Systemic treatment affects the entire cutaneous organ and internal cellular environment via IV or IM routes.
Step 1
Preparation & Setup
Assessment
Evaluate patient vital signs, confirm hydration status, and rule out contraindications such as severe asthma or sulfa allergies.
Reconstitution
Draw up Sterile Water or Vitamin C solution and inject into the Glutathione powder vial. Gently swirl — do not shake — until fully dissolved.
IV Drip Prep
Inject reconstituted mixture into a 50–250ml bag of 0.9% Normal Saline. Prime the IV line to ensure no air bubbles are present.
IM Preparation
Draw reconstituted mixture (typically 600mg Glutathione with 4ml sterile water) into a syringe fitted with a 21G or 23G needle for deep intramuscular injection.
Step 2
Clinical Administration
Intravenous (IV) Drip Protocol
Locate a viable vein (typically the median cubital vein) and insert a 22G or 24G IV cannula. Connect the primed IV line and set the drip rate for a slow, controlled infusion over 15 to 30 minutes.
Intramuscular (IM) Protocol
Utilise the Z-track method for deep gluteal injection (upper outer quadrant) to minimise subcutaneous irritation and product leakage.
Session Frequency
Administer 1 to 2 times per week for an initial cycle of 10 to 12 sessions. Maintenance: 1 to 2 sessions per month.
Step 3
Immediate Post-Care
Extraction
Carefully remove the IV cannula or IM needle. Apply firm pressure with sterile gauze for 2–3 minutes to prevent haematoma formation.
Observation
Keep the patient under observation for 10–15 minutes post-infusion to monitor for adverse reactions such as dizziness or mild hypotension.
Hydration Advice
Instruct the patient to drink at least 500ml of water immediately following the session to aid systemic circulation and cellular uptake.
Standard Clinical Protocol & Dosage
1200mg
Max Per Session
600–1200mg Glutathione, combined with 500–1000mg Vitamin C
2400mg
Weekly Maximum
Do not exceed without comprehensive physician oversight and renal monitoring
12
Initial Sessions
10–12 sessions at 1–2 per week for a full brightening cycle
Practitioner Guidelines
- Aseptic Protocol: Strict sterile technique is mandatory for reconstitution and venous access
- Hydration Verification: Confirm adequate hydration prior to cannula insertion
- Speed of Administration: Slow drip (15–30 min) is imperative — rapid infusion risks adverse reactions and rapid renal excretion before cellular absorption
Comprehensive Aftercare
1
0–24 Hours
Keep the IV/IM site clean and dry. Apply a cold compress for minor bruising. Avoid heavy alcohol consumption to allow the liver to process the antioxidant payload.
2
24 hrs – 2 Weeks
Maintain high water intake (2–3 litres daily) to flush released toxins. Strict adherence to broad-spectrum SPF 50+ is required as skin may become more photosensitive while melanin production is suppressed.
3
Expected Sensations
Mild tenderness or a small bruise at the IV/IM site is normal. Some patients report a mild, temporary metallic taste during infusion or a feeling of deep relaxation post-treatment.
Contraindications, Safety & Pro Tips
Contraindications
Asthma
May trigger bronchospasms; avoid in severe or uncontrolled asthma.
Allergies
Contraindicated with known Glutathione or severe sulfa allergies (cross-reactivity risk).
Organ Dysfunction
Contraindicated in severe renal failure or advanced hepatic disease unless cleared by a specialist.
Pregnancy & Lactation
Safety not established; strictly contraindicated.
Pro Tips & Best Practices
Clinical Pearl: Always pair Glutathione with high-dose Vitamin C. It acts as a catalyst, keeping Glutathione in its active (reduced) state and maximising tyrosinase-inhibiting efficacy.
Safety Warning: Avoid rapid IV pushes. Administering too quickly can cause sudden hypotension, dizziness, or stomach cramping. Always use a controlled drip over 15–30 minutes.
Retention Strategy: Sell treatments in "Cellular Detox & Brightening Cycles" of 10 sessions. Patients rarely see profound results until session 5 or 6 — a package ensures commitment to the full clinical timeline.
BlaqueSigma Professional Disclaimer
For Professional Use Only. This guide is intended for educational and reference purposes for certified aesthetic practitioners. It does not replace formal medical training. Practitioners are solely responsible for patient assessment, sterile application, and adhering to local regulatory guidelines. No refunds are provided on professional consumables.
Certified Practitioners Only
Ensure all treatments are performed by qualified, licensed professionals.
Regulatory Compliance
Adhere strictly to your local regulatory and clinical governance guidelines.
Patient Safety First
Thorough patient assessment and informed consent are mandatory before every session.